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(2018) Witkin et al. Bioisosteres of Ethyl 8-Ethynyl-6-(Pyridin-2-yl)-4H- benzo[f]imidazo [1, 5-a][1,4]diazepine-3-carboxylate (HZ-166) as Novel Alpha 2,3 Selective Potentiators of GABAA Receptors: Improved Bioavailability Enhances Anticonvulsant Efficacy
Publication
Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: improved bioavailability enhances anticonvulsant efficacy
Author: Witkin JM, Smith JL, Ping X, Gleason SD, Poe MM, Li G, Jin X, Hobbs J, Schkeryantz JM, McDermott JS, Alatorre AI, Siemian JN, Cramer JW, Airey DC, Methuku KR, Tiruveedhula VVNPB, Jones TM, Crawford J, Krambis MJ, Fisher JL, Cook JM, Cerne R.
Product: Neural Module, Maestro Pro, Maestro Edge,
(2018) Sarkar et al. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro
Publication
Efficient generation of CA3 neurons from human pluripotent stem cells enables modeling of hippocampal connectivity in vitro
Author: Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH.
Product: Neural Module, Maestro Pro, Maestro Edge,
Axion Bio - Culture Protocol - CDI Cardiomyocytes2
Culture Protocol
CDI iCell Cardiomyocytes^2 Application Protocol
Author: Axion BioSystems
Product: Maestro Pro, Cardiac Module, CytoView MEA Plate, Maestro Edge,
2018_toxicolsci_millard_crosssitereliabilityof.png
Publication
Cross-site reliability of human induced pluripotent stem-cell derived cardiomyocyte based safety assays using microelectrode arrays: Results from a blinded CiPA Pilot Study
Author: Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G.
Product: Maestro Pro, Maestro Edge, Cardiac Module,
2018_jove_sanchez_assessmentoftheeffects.png
Publication
Assessment of the effects of endocrine disrupting compounds on the development of vertebrate neural network function using multi-electrode arrays
Author: Sanchez KR, Mersha MD, Dhillon HS, Temburni MK.
Product: Neural Module,
2018_cerebralcortex_valente_constitutiveinactivationofthe.png
Publication
Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons
Author: Valente P, Romei A, Fadda M, Sterlini B, Lonardoni D, Forte N, Fruscione F, Castroflorio E, Michetti C, Giansante G, Valtorta F, Tsai JW, Zara F, Nieus T, Corradi A, Fassio A, Baldelli P, Benfenati F.
Product: Neural Module, Maestro Pro, Maestro Edge,
Axion Bio App Note Zebrafish
Application Note
Zebrafish Assays
Author: Axion BioSystems
Product: Maestro Pro, Neural Module, Lumos, CytoView MEA Plate, Maestro Edge,
2018_cellstemcell_rajamani_superobesepatientderived.png
Publication
Super-obese patient-derived iPSC hypothalamic neurons exhibit obesogenic signatures and hormone responses
Author: Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, Gangalapudi V, Wang Y, Andres AM, Gottlieb RA, Sareen D.
Product: Neural Module, Maestro Pro, Maestro Edge,
2018_toxicolapplpharmacol_kreir_doinvitroassays.png
Publication
Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?
Author: Kreir M, Van Deuren B, Versweyveld S, De Bondt A, Van den Wyngaert I, Van der Linde H, Lu HR, Teuns G, Gallacher DJ.
Product: Neural Module, Maestro Pro, Maestro Edge,
2018_neurotoxicology_zwartsen_neurotoxicityscreeningofnew.png
Publication
Neurotoxicity screening of new psychoactive substances (NPS): effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA)
Author: Zwartsen A, Hondebrink L, Westerink RHS.
Product: Neural Module, Maestro Pro, Maestro Edge,
2018_brain_fruscione_prrt2controlsneuronalexcitability.png
Publication
PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity
Author: Fruscione F, Valente P, Sterlini B, Romei A, Baldassari S, Fadda M, Prestigio C, Giansante G, Sartorelli J, Rossi P, Rubio A, Gambardella A, Nieus T, Broccoli V, Fassio A, Baldelli P, Corradi A, Zara F, Benfenati F.
Product: Neural Module, Maestro Pro, Maestro Edge, CytoView MEA Plate,
2018 SOT Optogenetic pacing poster
Poster
Optogenetic pacing for assessment of proarrhythmic potential of drugs in induced pluripotent stem cell derived cardiomyocytes
Author: Patel D, Stohlman J, Strauss D, Blinova K.
Product: Maestro Pro, Maestro Edge, Lumos MEA Plate, Lumos, Cardiac Module,
2018 SOT Fermini poster
Poster
Inter-individual differences in electrophysiology, pharmacology and drug responses in a cohort of hiPSC-derived cardiomyocytes: Endorsing clinical trials-in-a-dish
Author: Fermini B, Sullivan D, Chal J, Fine E, Hernandez AU, King A, Johnson J, Coyne S, Coyne KP.
Product: Maestro Pro, Cardiac Module, Maestro Edge,
2018_cellstemcell_ziller_dissectingthefunctionalconsequences.png
Publication
Dissecting the functional consequences of de novo DNA methylation dynamics in human motor neuron differentiation and physiology
Author: Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, Kiskinis E.
Product: Neural Module, Maestro Pro, Maestro Edge,
2018 poster hari thiol containing compounds
Poster
Thiol-containing compounds attenuate oxidative stress and neuronal hyperexcitability in vitro
Author: Hari AS, Liang LP, Yang D, Day BJ, Patel M.
Product: Maestro Pro, Neural Module, Maestro Edge,
2017_sps_kim_multiparametricassessmentofnetworked.png
Poster
Multiparametric assessment of networked electrical activity using induced pluripotent stem cell-derived glutamatergic neurons
Author: Kim KH, Carlson CB, Kannemeier C, Feaster TK, Swanson B, Schlesinger D, Anson BD, Mangan KP.
Product: Neural Module, Maestro Pro, Maestro Edge,
2018 poster sot kirby refining in vitro q patch
Poster
Refining in vitro QPatch cardiac ion channel and MEA iPSC-derived cardiomyocyte assays for CiPA
Author: Kirby RW, Haou SE, Humphries E, Williams S, Webdale L, Sutton K, Rogers M.
Product: Maestro Pro, Cardiac Module, Maestro Edge,
2018 SOT poster hess optimization of human stem cell
Poster
Optimization of human stem cell derived neuron/astrocyte co-culture system for seizure liability assessment using microelectrode arrays
Author: Hess D, Fleming C, Palm T, Ehlich A, Luerman G, Bohlen H, Braam S.
Product: Maestro Pro, Neural Module,
2018 SOT poster clements characterization of the local extracellular
Poster
Characterization of the local extracellular action potential (LEAP) signal for use in cardiac safety evaluation
Author: Clements M, Hayes HB, Nicolini, AM, Arrowood CA, Millard DC.
Product: Maestro Pro, Cardiac Module, Maestro Edge,
2018 SOT poster clements optimization of optogenetics
Poster
Optimization of optogenetic transduction of stem cell derived cardiomyocytes with adeno-associated virus for optically-paced cardiac electrophysiology assays
Author: Clements M, Hayes HB, Nicolini, AM, Arrowood CA, Millard DC.
Product: Maestro Pro, Cardiac Module, Lumos, Lumos MEA Plate, Maestro Edge,