Authors: Shotaro Matsumoto, Maret G Traber, Scott W Leonard, Jaewoo Choi, Xiaohui Fang, Mazharul Maishan, Katherine D Wick, Kirk D Jones, Carolyn S Calfee, Jeffrey E Gotts, and Michael A Matthay
The American Journal of Physiology-Lung Cellular and Molecular Physiology, 1 June 2022
Vitamin E acetate (VEA) is thought to play a causal role in the development of vaping-associated lung injury. The authors of this study aimed to identify the exact mechanisms promoting VEA-related lung injury. The Axion BioSystems Exact (former Corning cell counter) was used to count bronchoalveolar lavage (BAL) cells. The results suggested that extended exposure to VEA aerosol produced systemic inflammation and evidence of systemic oxidative stress in mice, providing evidence of these processes as possible pathways for the harmful effects of VEA in smokers.
