Hypersensitivity and Induced Radioresistance in Chinese Hamster Cells Exposed to Radiations with Different LET Values

Authors: Ekaterina Koryakina, Vladimir I. Potetnya, Marina Troshina, Raisa Baykuzina, Sergey Koryakin, Anatoliy Lychagin, Aleksei Solovev, Vyacheslav Saburov, Vladimir Pikalov, Petr Shegay, Sergey Ivanov and Andrey Kaprin

International Journal of Molecular Science, 17 June 2022

The authors of this study investigated the impact of radiation linear energy transfer (LET) on manifestation of hyper-radiosensitivity and radioresistance (HRS/IRR) response in CHO-K1 cells exposed to radiations used in radiotherapy. The Axion BioSystems Exact (formerly known as Corning Cell Counter) was used to quantify CHO-K1 cells before seeding cells for subsequent irradiation experiments. Taken together, the results show a certain dependence of HRS/IRR response on the LET.