Viral infection can cause changes in morphology, viability, and alter cell-cell interactions in host cells. These changes, known as cytopathic effects (CPE), can be drastic or subtle, occur quickly or over long periods of time, and can be detected by impedance. The Maestro impedance assay can continuously monitor in vitro viral infections in real time, with stable environmental control, high throughput, and the flexibility and sensitivity to capture the full range of effects.