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npj Parkinson's Disease, 31 March 2026
Publication
Autophagy dysfunction in iPSCs-derived neurons and midbrain organoids carrying a SNCA triplication
Author: C. Serra-Almeida, J. Jarazo, G. Gomez-Giro, I. Rosety, A. Zagare, D. Ferrante, C. Saraiva, D. Frangenberg, J. Modamio-Chamarro, E. Zuccoli, A. C. Cristóvão, L. Bernardino, and J. C. Schwamborn
Product: Maestro MEA, Neural Module, CytoView MEA Plate,
Maestro MEA: Optimized for Organoids
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Advancing Organoid Research Through MEA Innovation
Axion BioSystems
Product: Maestro Edge, Maestro Pro, Neural Module, MEA Creator Kit, Organoid MEA,
Materials Today Bio Publication, 05 Feb 2024
Publication
Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions
Author: A. Ozgun, D. J. Lomboni, A. Aylsworth, A. Macdonald, W. A. Staines, M. Martina, M. G. Schlossmacher, J. S. Tauskela, J. Woulfe, and F. Variola
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Communications Biology, 23 November 2024
Publication
Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids
Author: K. Barmpa, C. Saraiva, D. Lopez-Pigozzi, G. Gomez-Giro, E. Gabassi, S. Spitz, K. Brandauer, J. E. Rodriguez Gatica, P. Antony, G. Robertson, R. Sabahi-Kaviani, A. Bellapianta, F. Papastefanaki, R. Luttge, U. Kubitscheck, A. Salti, P. Ertl, M. Bortolozzi, R. Matsas, F. Edenhofer and J. C. Schwamborn
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Nature Neuroscience, 08 October 2024
Publication
Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Author: A. Bayati, R. Ayoubi, A. Aguila, C. E. Zorca, G. Deyab, C. Han, S. J. Recinto, E. Nguyen-Renou, C. Rocha, G. Maussion, W. Luo, I. Shlaifer, E. Banks, I. McDowell, E. D. C. Pellitero, X. E. Ding, B. Sharif, P. Séguéla, M. Yaqubi, C. X.-Q. Chen, Z. You, N. Abdian, H. M. McBride, E. A. Fon, J. A. Stratton, T. M. Durcan, P. C. Nahirney and P. S. McPherson
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Science Advances, 11 September 2024
Publication
Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs
Author: Y. Jin, F. Li, Z. Li, T. C. Ikezu, J. O’Leary, M. Selvaraj, Y. Zhu , Y. A. Martens, S. Koga, H. Santhakumar, Y. Li , W. Lu, Y. You, K. Lolo, M. DeTure, A. I. Beasley, M. D. Davis, P. J. McLean, O. A. Ross, T. Kanekiyo, T. Ikezu, T. Caulfield, J. Carr, Z. K. Wszolek, G. Bu, D. W. Dickson, and N. Zhao
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
npj Parkinson's Disease, 28 July 2024
Publication
Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease
Author: F. E. Kapucu, I. Tujula, O. Kulta, L. Sukki, T. Ryynänen, H. Gram, V. Vuolanto, A. Vinogradov, J. Kreutzer, P. H. Jensen, P. Kallio, and S. Narkilahti
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Nature Cell Biology, 01 July 2024
Publication
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates
Author: C. Wang, K. Zhang, B. Cai, J. E. Haller, K. E. Carnazza, J. Hu, C. Zhao, Z. Tian, X. Hu, D. Hall, J. Qiang, S. Hou, Z. Liu, J. Gu, Y. Zhang, K. B. Seroogy, J. Burré, Y. Fang, C. Liu, A. T. Brunger, D. Li and J. Diao
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Parkinson's Disease Publication Highlight
Flyer
Parkinson’s Disease
Author: Axion BioSystems
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
npj Parkinson's Disease Publication, December 2023
Publication
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids
Author: I. Rosety, A. Zagare, C. Saraiva, S. Nickels, P. Antony, C. Almeida, E. Glaab, R. Halder, S. Velychko, T. Rauen, H. R. Schöler, S. Bolognin, T. Sauter, J. Jarazo, R. Krüger and J. C. Schwamborn
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
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Publication
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients
Author: Stern S, Lau S, Manole A, Rosh I, Percia MM, Ezer RB, Shokhirev MN, Qiu A, Schafer S, Mansour AA, Mangan KP, Stern T, Ofer P, Stern Y, Mendes APD, Djamus J, Moore LR, Nayak R, Laufer SH, Aicher A, Rhee A, Wong TL, Nguyen T, Linker SB, Winner B, Freitas BC, Jones E, Sagi I, Bardy C, Brice A, Winkler J, Marchetto MC, Gage FH
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Structure vs. Function in Cerebral Organoids: How and Why to Study Both
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Contract Pharma - Structure vs. Function in Cerebral Organoids: How and Why to Study Both
Author: David Ferrick, Ph.D., Chief Scientific Officer of Axion BioSystems
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Publication
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α- Synucleinopathy models
Author: Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F.
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
2020_stemcellreviewsandreports_xiang_roleofchromatinremodeling
Publication
Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons
Author: Xiang L, Huang G, Shu W, Gong C, Cao N, Chen R, Li J, Lu H, Jiang G.
Product: Maestro Pro, Neural Module, CytoView MEA Plate, Maestro Edge,
2020_naturemedicine_laperle_ipscmodelingofyoung
Publication
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates
Author: Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR2, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, Van Eyk JE, Tagliati M, Svendsen CN.
Product: Maestro Pro, Neural Module, Maestro Edge,
2020_journalofclinicalinvestigation_song_humanautologousipscderived
Publication
Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models
Author: Song B, Cha Y, Ko S, Jeon J, Lee N, Seo H, Park KJ, Lee IH, Lopes C, Feitosa M, Luna MJ, Jung JH, Kim J, Hwang D, Cohen BM, Teicher MH, Leblanc P, Carter BS, Kordower JH, Bolshakov VY, Kong SW, Schweitzer JS, Kim KS.
Product: Maestro Pro, Neural Module, CytoView MEA Plate, Maestro Edge,
2019_stemcellres_leitner_immaturemdaneuronsameliorate.png
Publication
Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation
Author: Leitner D, Ramamoorthy M, Dejosez M, Zwaka TP.
Product: Maestro Pro, Neural Module, Maestro Edge,
AxionBio App Note Parkinsons Disease
Application Note
Parkinson's Disease
Author: Axion BioSystems
Product: Maestro Pro, Neural Module, CytoView MEA Plate, Maestro Edge,
2018_natcommun_guiberson_mechanismbasedrescueof.png
Publication
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones
Author: Guiberson NGL, Pineda A, Abramov D, Kharel P, Carnazza KE, Wragg RT, Dittman JS, Burre J.
Product: Neural Module, Maestro Pro, Maestro Edge, CytoView MEA Plate,
(2017) Monzel et al. Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Publication
Derivation of human midbrain-specific organoids from neuroepithelial stem cells
Author: Monzel AS, Smits LM, Hemmer K, Hachi S, Moreno EL, van Wuellen T, Jarazo J, Walter J, Brüggemann I, Boussaad I, Berger E, Fleming RMT, Bolognin S, Schwamborn JC.
Product: Neural Module, Maestro Pro, Maestro Edge,