Resources
Advanced Science, 27 January 2026
Publication
Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids
Author: S. R. Labra, J. Compher, A. Prabhavalkar, M. Almaraz, C. C. Kwong, C. Baal, M. Talantova, N. Dolatabadi, J. Piña-Sanz, Y. Wang, L. Yoon, S. Ghatak, Z. Gao, Y. Zhang, D. Trudler, L. Massey, W. Lin, A. Balistreri, M. Bula, N. J. Schork, T. S. Mondala, S. R. Head, J. W. Kelly, and S. A. Lipton
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Neuropharmacology, 14 April 2025
Publication
Activation of Epac2 improves Aβ-induced impairment of memory retrieval in an acute model of Alzheimer's disease
Author: T. Zhang, Y. Zhang, P. Chameau, T. Chen, A. Marmolejo-Garza, W. Douwenga, A. M. Dolga, H. W. Kessels, M. Schmidt, and U. L.M. Eisel
Product: Maestro MEA, Neural Module, CytoView MEA Plate,
Neuron, 23 December 2024
Publication
A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
Author: A. Flury, L. Aljayousi, H. Park, M. Khakpour, J. Mechler, S. Aziz, J. D. McGrath, P. Deme, C. Sandberg, F. G. Ibáñez, O. Braniff, T. Ngo, S. Smith, M. Velez, D. M. Ramirez, D. Avnon-Klein, J. W. Murray, J. Liu, M. Parent, S. Mingote, N. J. Haughey, S. Werneburg, M. Tremblay, and P. Ayata
Product: Maestro Pro, CytoView MEA Plate, Neural Module,
Bio-Diamond Project Translational brain-on-a-chip models for Alzheimer's Disease Drug Discovery
Poster
Bio-Diamond Project: Translational brain-on-a-chip models for Alzheimer's Disease Drug Discovery
Author: B. G. C. MAISONNEUVE, A. ALLOUCHE, S. KRIDI, L. MINY, L. DIER, J. COLIN, J. RONTARD, N. VIOLLE, and T. HONEGGER
Product: Maestro Pro,
Molecular Neurodegeneration Publication, April 2024
Publication
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Author: L. Vandermeulen, I. Geric, L. Fumagalli, M. Kreir, A. Lu, A. Nonneman, J. Premereur, L. Wolfs, R. Policarpo, N. Fattorelli, A. De Bondt, I. Van Den Wyngaert, B. Asselbergh, M. Fiers, B. De Strooper, C. d’Ydewalle and R. Mancuso
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
thumbnail of publication
Publication
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
Author: Lagomarsino VN, Pearse RV 2nd, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, and Young-Pearse TL.
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
human stem-cell derived test system for neuronal signaling on multiwell MEA system
Publication
A human stem cell‑derived test system for agents modifying neuronal N‑methyl‑d‑aspartate‑type glutamate receptor Ca2+‑signalling
Author: Klima S, Brüll M, Spreng A-S, Suciu I, Falt T, Schwamborn JC, Waldmann T, Karreman C, Leist M.
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
2021 Rybak wolf brain organoids with herpes
Publication
Neurodegeneration in human brain organoids infected with herpes simplex virus type 1
Author: Rybak-Wolf A, Wyler E, Legnini I, Loewa A, Glažar P, Kim SJ, Pentimalli TM, Martinez AO, Beyersdorf B, Woehler A, Landthaler M and Rajewsky N.
Product: Maestro Pro, Neural Module, BioCircuit MEA Plate,
2020 Neuron Wang Publication on therapeutics for Alzheimers Disease
Publication
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
Author: Wang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang, Y-S, Neff R, Song W-M, Wang E, Shen Q, Zhou X, Ming C, Ho S-M, Vatansever S, Kaniskan HU, Jin J, Zhou M-M, Ando K, Ho L, Slesinger PA, Yue Z, Zhu J, Katsel P, Gandy S, Ehrlich ME, Fossati V, Noggle S, Cai D, Haroutunian V, Iijima KM, Schadt E, Brennand KJ, Zhang B.
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
2020_elife_voskobiynyk_alzheimers1diseaseriskgene
Publication
Alzheimer’s 1 disease risk gene BIN1 induces Tau-dependent network hyperexcitability
Author: Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ.
Product: Maestro Pro, Neural Module, BioCircuit MEA Plate, Maestro Edge,
2020_molpsychiarty_ghatak_nitrosynapsinameliorateshypersynchronousneural
Publication
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models
Author: Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B, Lipton SA.
Product: Maestro Pro, Neural Module, Maestro Edge,
2020_cells_ishikawa_mirnabasedrapiddifferentiation
Publication
miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advances towards Quick Screening for Neuronal Disease Phenotypes In Vitro
Author: Ishikawa M, Aoyama T, Shibata S, Sone T, Miyoshi H, Watanabe H, Nakamura M, Morota S, Uchino H, Yoo AS, Okano H.
Product: Maestro Pro, Neural Module, CytoView MEA Plate, Maestro Edge,
2020_frontimmunol_Li_activatedbonemarrowderived
Publication
Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related AB Oligomers and Protect Synapses
Author: Li S, Hayden EY, Garcia VJ, Fuchs D-T, Sheyn J, Daley DA, Rentsendorj A, Torbati T, Black KL, Rutishauser U, Teplow DB, Koronyo Y and Koronyo-Hamaoui M.
Product: Maestro Pro, Neural Module, Maestro Edge,
2019_elife_ghatak_mechanismsofhyperexcitabilityin.png
Publication
Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic controls
Author: Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA.
Product: Maestro Pro, Neural Module, CytoView MEA Plate, Maestro Edge,
2019_neuron_sohn_pathogenictauimpairsaxon.png
Publication
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis
Author: Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.
Product: Neural Module, Maestro Pro, Maestro Edge,
2019_jneurosci_fleck_ptcd1isrequiredfor.png
Publication
PTCD1 Is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease
Author: Fleck D, Phu L, Verschueren E, Hinkle T, Reichelt M, Bhangale T, Haley B, Wang Y, Graham R, Kirkpatrick DS, Sheng M, Bingol B.
Product: Maestro Pro, Neural Module, CytoView MEA Plate, Maestro Edge,
2018_actaneuropatholcommun_kajiwara_gja1connexin43isa.png
Publication
GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis
Author: Kajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, Naus CC, Buxbaum J, Zhang B.
Product: Maestro Pro, Neural Module, Maestro Edge,
2018_alzheimersdement_garcialeon_generationofahuman.png
Publication
Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
Author: Garci­a-Leon JA, Cabrera-Socorro A, Eggermont K, Swijsen A, Terryn J, Fazal R, Nami F, Ordovas L, Quiles A, Lluis F, Serneels L, Wierda K, Sierksma A, Kreir M, Pestana F, Van Damme P, De Strooper B, Thorrez L, Ebneth A, Verfaillie CM.
Product: Neural Module, Maestro Pro, Maestro Edge,
2018_natcommun_guiberson_mechanismbasedrescueof.png
Publication
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones
Author: Guiberson NGL, Pineda A, Abramov D, Kharel P, Carnazza KE, Wragg RT, Dittman JS, Burre J.
Product: Neural Module, Maestro Pro, Maestro Edge, CytoView MEA Plate,
2017 SfN Manga Identification of measurable phenotypes
Poster
Identification of measurable phenotypes relevant to Alzheimer's disease using human iPSC-derived neurons
Author: Mangan K, Harms L, Enghofer E, Kannemeier C, Kim KH, Czysz, K, Bader B, Jugelt K, Schroder O, Frietas B and Jones E.
Product: Maestro Pro, Neural Module, Maestro Edge,