New frontiers in cardiac organoid research
Three-dimensional cardiac organoids offer more physiologically relevant in vitro cell models of the human heart, enabling scientists to better mimic the complex structure and cellular environment found in vivo.
Discover how researchers are using 3D cardiac organoids on Axion BioSystems’ hands-free Maestro MEA platform to improve disease modeling, accelerate drug screening, reduce reliance on animal models, and facilitate the development of novel therapeutic approaches for heart disease.
Featured publications
>> Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids
Demonstrating human iPSC-derived cardiac organoids as “a reliable and physiologically relevant platform for assessing cardiotoxicity and drug safety,” scientists evaluate the cardiotoxicity and safety of Echinochrome A.
Lee S-J et al. (2025). Ecotoxicology and Environmental Safety.
>> Protocol to study electrophysiological properties of hPSC-derived 3D cardiac organoids using MEA and sharp electrode techniques
Researchers describe a detailed protocol for assessing the electrical properties of 3D human pluripotent stem cell-derived cardiac organoids using Maestro Pro multielectrode array (MEA) and manual electrophysiology.
Venkateshappa R et al. (2024). Star Protocols.
>> Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models
The authors use whole exome sequencing to identify a candidate gene causing dilated cardiomyopathy in a large family, then explore the underlying mechanisms using rodent models and stem cell-derived cardiac organoids.
Li Y et al. (2024). The Journal of Clinical Investigation.
>> Generation of human iPSCs derived heart organoids structurally and functionally similar to heart
Scientists present an optimized, Matrigel-based protocol to generate functional human-induced pluripotent stem cell-derived heart organoids optimized for use with Maestro Edge MEA in cardiac disease research and drug development.
Lee S-G et al. (2022). Biomaterials.
>> Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids
Song M et al. (2024). Cell Death & Disease.
“Overall, currently the best MEA system on the market for analysis of cardiomyocytes.”
An easy-to-use system that offers a complete solution without the need for additional software or electrophysiological or bioinformatic skills. When you identify a proper way to plate your cells of interest in the MEA multi-well plates, measurements and data analysis is straightforward and the results are reproducible and of high-quality.
- L.C., University Medical Center Goettingen - Stem Cell Unit
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Our specialists are available to provide more information about our systems for cardiac organoid assays.
