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Publication Highlights April 2023
Flyer
Amyotrophic lateral sclerosis (ALS)
Author: Axion BioSystems
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Neurobiology of Disease Publication (Volume 181, 1) June 2023
Publication
hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons
Author: C. Lee, J. Frew, N. Weilinger, S. Wendt, W. Cai, S. Sorrentino, X. Wu, B. MacVicar, S. Willerth, and H. Nygaard
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Journal of Virology Publication (Volume 97, Issue 4), Apr 2023
Publication
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
Author: P. Kettunen, A. Lesnikova, N. Räsänena, R. Ojha, L. Palmunen, M. Laaksoc, Š. Lehtonen, J. Kuusisto, O. Pietiläinen, S. Saber, M. Joensuu, O. Vapalahti, J. Koistinaho, T. Rolova, G. Balistreri
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
GLIA Publication 08 April 2023
Publication
Transcription factor combinations that define human astrocyte identity encode significant variation of maturity and function
Author: K. Baranes, N. Hastings, S. Rahman, N. Poulin, J. Tavares, W. Kuan, N. Syed, M. Kunz, K. Blighe, T. Belgard, and M. Kotter
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Cell Stem Cell, Volume 30 Issue 4
Publication
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
Author: Marchiano S, Nakamura K, Reineck H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, Klaiman JM, Blakely LP, Karbassi E, Fields PA, Fenix AM, Beussman KM, Jayabalu A, Kalucki FA, Futakuchi-Tsuchida A, Weber GJ, Dupras S, Tsuchida H, Pabon L, Wang L, Knollmann BC, Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A, Murry CE.
Product: Maestro Edge, Cardiac Module, CytoView MEA Plate,
Repeated Challenge Assay App Note
Application Note
Development of a repeated challenge assay to evaluate immune cell-mediated cytotoxicity in vitro
Author: Denise Sullivan & Daniel Millard
Axion BioSystems, Atlanta, GA
Product: Maestro Z, Impedance Module, CytoView-Z Plate,
Using Rabbit Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Investigate Drug-Induced Fetal Heart Malformations
Publication
Using Rabbit Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Investigate Drug-Induced Fetal Heart Malformations
Author: John T. Szilagyi and Kyle L. Kolaja
Product: Maestro Edge, Cardiac Module, BioCircuit MEA Plate,
Front. Physiol., 21 March 2023
Publication
The three-dimensionality of the hiPSC-CM spheroid contributes to the variability of the field potential
Author: Minki Hwang1, Su-Jin Lee 2, Chul-Hyun Lim, Eun Bo Shim and Hyang-Ae Lee
Product:
Emma Kasteel, Utrecht University
Poster
In vitro neurotoxicity of micro- and nanoplastics measured using microelectrode array (MEA) recordings in rat cortical cultures
Author: Emma E.J. Kasteel and Remco H.S. Westerink
Product: Maestro Pro, Neural Module,
Poster - Sarah Jolly, ARUK-UCL Drug Discovery Institute; UCL
Poster
Modelling of glia-neuron crosstalk in vitro to facilitate drug discovery for Alzheimer’s disease
Author: Sarah Jolly, Leela Phadke, Dawn H.W. Lau, Nozie D. Aghaizu, Shania Ibarra, Carmen M. Navarron, Lucy
Granat, Lorenza Magno, Paul Whiting, Paul V. Fish, Fiona Ducotterd
Product: Maestro Pro, Neural Module,
A role for the primary cilium in network properties of neurons
Poster
A role for the primary cilium in network properties of neurons
Author: Emma Dyke, Chantal Bijnagte-Schoenmaker, Rachel Mijdam, Lisa Rahm, Marie Le Bihan, Ummi
Ciptasari, Jindřiška Leischner Fialová, Brooke Latour, Dirk Schubert, Ronald Roepman, Nael Nadif Kasri
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Modeling epilepsy-related SCN2A mutation L1342P with CRISPR/Cas9-edited human-induced pluripotent stem cell-derived cortical spheroids
Poster
Modeling epilepsy-related SCN2A mutation L1342P with CRISPR/Cas9-edited human-induced pluripotent stem cell-derived cortical spheroids
Author: Maria I. Olivero-Acosta, Zhefu Que, Conrad Otterbacher, Muhan Wang, Trang Nguyen, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Jiaxiang Wu, William C, Skarnes, Yang Yang
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Properties of Human Stem Cell-derived Neurons in Long-term Cell Culture as a Model for Antiseizure Drug Discovery
Poster
Properties of Human Stem Cell-derived Neurons in Long-term Cell Culture as a Model for Antiseizure Drug Discovery
Author: Hamed Salmanzadeh and Robert F. Halliwell
Product: Maestro Edge, CytoView MEA Plate, Neural Module,
Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter in spinal muscular atrophy is not fully restored after lentiviral SMN delivery
Poster
Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter in spinal muscular atrophy is not fully restored after lentiviral SMN delivery
Author: Emily Welby, Ph.D.
Product: CytoView MEA Plate, Neural Module,
Evaluating the Influence of HCMV Infection on Alzheimer’s Disease Pathology
Poster
Evaluating the Influence of HCMV Infection on Alzheimer’s Disease Pathology
Author: Jacob W. Adelman, Megan L. Schumacher, Benjamin S. O’Brien, Suzette Rosas-Rogers, Scott S. Terhune, Allison D. Ebert
Product: CytoView MEA Plate, Neural Module,
Liquid tumor app note
Application Note
Development of an in vitro cell killing assay for liquid tumor cancer cells
Author: Axion BioSystems
Product: Maestro Z, Impedance Module, CytoView-Z Plate,
Biological Psychiatry Publication 13 March 2023
Publication
Loss of CNTNAP2 alters human cortical excitatory neuron differentiation and neural network development
Author: F. George-Hyslop, M. Haneklaus, T. Kivisild, F. Livesey
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
OmniFL-publication_Neuro
Publication
Elevated ROS levels during the early development of Angelman syndrome alter the apoptotic capacity of the developing neural precursor cells
Author: Lilach Simchi, Pooja Kri Gupta, Yonatan Feuermann, and Hanoch Kaphzan
Product: Omni,
2023 Renal Physiology Functional TFEB activation characterizes multiple models of renal cystic disease
Publication
Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1
Author: Shillingford JM and Shayman JA
Product: Exact FL, Cell Counting Module, Corning Cell Counter,
Electrically-evoked oscillating calcium transients in mono- and co-cultures of iPSC glia and sensory neurons
Publication
Electrically-evoked oscillating calcium transients in mono- and co-cultures of iPSC glia and sensory neurons
Author: Jennifer Lawson, Eli LaVancher, Mauricio De Almeida, and Bryan J. Black
Product: Neural Module, Maestro Pro, CytoView MEA Plate,