Resources
Scientific Reports, 29 April 2025
Publication
Seizure-like behavior and hyperactivity in napb knockout zebrafish as a model for autism and epilepsy
Author: K. C. Shin, W. Hasan, G. Ali, D. Abdelrahman, T. Abuarja, L. W. Stanton, S. I. Da’as and Y. Park
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Redox Biology, 13 February 2025
Publication
Selenium deficiency impedes maturation of parvalbumin interneurons, perineuronal nets, and neural network activity
Author: A. R. Sasuclark, M. Watanabe, K. Roshto, V. W. Kilonzo, Y. Zhang, and M. W. Pitts
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Advanced Science, 31 December 2024
Publication
Personalized Human Astrocyte-Derived Region-Specific Forebrain Organoids Recapitulate Endogenous Pathological Features of Focal Cortical Dysplasia
Author: J. Xu, Y. Kong, N. Wang, H. Li, Y. Li, Z. Liu, Y. Yang, X. Yu, H. Liu, J. Ding, Y. Wang, R. Zhao, and Z. Shao
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Brain, 26 October 2024
Publication
CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability
Author: M. P. Hommersom, N. Doorn, S. Puvogel, E. I. Lewerissa, A. Mordelt, U. Ciptasari, F. Kampshoff, L. Dillen, E. van Beusekom, A. Oudakker, N. Kogo, A. M. Dolga, M. Frega, D. Schubert, B. P. C. van de Warrenburg, N. N. Kasri, and H. van Bokhoven
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Frontiers in Network Physiology, 02 September 2024
Publication
Modeling seizure networks in neuron-glia cultures using microelectrode arrays
Author: U. Boddeti, J. Langbein, D. McAfee, M. Altshuler, M. Bachani, H. P. Zaveri, D. Spencer, K. A. Zaghloul, and A. Ksendzovsky
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Nature Communications, 04 July 2024
Publication
A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level
Author: Assunta Merolla, Caterina Michetti, Matteo Moschetta, Francesca Vacca, Lorenzo Ciano, Laura Emionite, Simonetta Astigiano, Alessandra Romei, Simone Horenkamp, Ken Berglund, Robert E. Gross, Fabrizia Cesca, Elisabetta Colombo and Fabio Benfenati
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Cell Reports Publication, May 2024
Publication
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
Author: N. K. Dhaliwal, O. Y. Weng, X. Dong, A. Bhattacharya, M. Ahmed, H. Nishimura, W. W.Y. Choi, A. Aggarwal, B. W. Luikart, Q. Shu, X. Li, M. D. Wilson, J. Moffat, L. Y. Wang, J. Muffat, and Y. Li
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Frontiers in Pharmacology Publication, May 2024
Publication
Antiseizure properties of fenamate NSAIDs determined in mature human stem-cell derived neuroglial circuits
Author: H. Salmanzadeh, and R. F. Halliwell
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Maestro Volt MEA system launched by Axion BioSystems
News
Axion BioSystems Adds Affordable Maestro Volt to its Industry-Leading MEA System Lineup
Author: Axion BioSystems
Product: Maestro Volt, Neural Module, Cardiac Module, CytoView MEA Plate,
Neural Organoid Workflow Webinar
Video
Standardizing organoid production and analysis
Mike Clements, PhD
Product: Omni, Maestro Pro, iPSC Module, Clonogenic Assay Module, Organoid Analysis Module, Neural Module, MEA Viability Module, SpheroGuide MEA Plate, CytoView MEA Plate,
Biological Psychiatry Global Open Science Publication, Jan 2024
Publication
Calcium dependent hyperexcitability in human stem cell derived Rett syndrome neuronal networks
Author: K. S. Pradeepan, F. P. McCready, W. Wei, M. Khaki, W. Zhang, M. W. Salter, J. Ellis, and J. Martinez-Trujillo
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Publication Highlight - Epilespy
Publication
Epilepsy Publication Highlight
Author: Axion BioSystems
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Neurobiology of Disease Publication, January 2024
Publication
ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations
Author: W. Afshar-Saber, N. A. Teaney, K. D. Winden, H. Jumo, X. Shi, G. McGinty, J. Hubbs, C. Chen, I. T. Latzer, F. Gasparoli, D. Ebrahimi-Fakhari, E. D. Buttermore, J. B. Roullet, P. L. Pearl, and M. Sahin
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Frontiers in Cellular Neuroscience Publication, May 18th 2023
Publication
Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor
Author: S. Colombo, H. Reddy, S. Petri, D. J. Williams, B. Shalomov, R. S. Dhindsa, S. Gelfman, D. Krizay, A. K. Bera, M. Yang, Y. Peng, C. D. Makinson, M. J. Boland, W. N. Frankel, D. B. Goldstein and N. Dascal
Product: CytoView MEA Plate, Neural Module,
JCI Publication 2023
Publication
Postoperative risk of IDH mutant glioma-associated seizures and their potential management with IDH mutant inhibitors
Author: M. Drumm, W. Wang, T. Sears, K. Bell-Burdett, R. Javier, K. Cotton, B. Webb, K. Byrne, D. Unruh, V. Thirunavu, J. Walshon, A. Steffens, K. McCortney, R. Lukas, J. Phillips, E. Mohamed, J. Finan, L. Santana-Santos, A. Heimberger, C. Franz, J. Kurz, J. Templer, G. Swanson, and C. Horbinski
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Modeling epilepsy-related SCN2A mutation L1342P with CRISPR/Cas9-edited human-induced pluripotent stem cell-derived cortical spheroids
Poster
Modeling epilepsy-related SCN2A mutation L1342P with CRISPR/Cas9-edited human-induced pluripotent stem cell-derived cortical spheroids
Author: Maria I. Olivero-Acosta, Zhefu Que, Conrad Otterbacher, Muhan Wang, Trang Nguyen, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Jiaxiang Wu, William C, Skarnes, Yang Yang
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
Scientists use Axion’s Maestro platform to investigate the role of MYT1L in autism spectrum disorders in vitro and uncover potential new therapeutic pathways.
Publication
MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention
Author: Bettina Weigel, Jana F. Tegethoff, Sarah D. Grieder, Bryce Lim, Bhuvaneswari Nagarajan, Yu-Chao Liu,
Jule Truberg, Dimitris Papageorgiou, Juan M. Adrian-Segarra, Laura K. Schmidt, Janina Kaspar, Eric Poisel,
Elisa Heinzelmann, Manu Saraswat, Marleen Christ, Christian Arnold, Ignacio L. Ibarra, Joaquin Campos,
Jeroen Krijgsveld, Hannah Monyer, Judith B. Zaugg, Claudio Acuna and Moritz Mall
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
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Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Author: BK Unda, L Chalil, S Yoon, S Kilpatrick, C Irwin, S Xing, N Murtaza, A Cheng, C Brown, A Afonso, E McCready, GM Ronen, J Howe, A Caye-Eude, A Verloes, BW Doble, L Faivre, A Vitobello, SW Scherer, Y Lu, P Penzes, KK Singh
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
The Pathologist Publication Cover
News
Organoids: Only as Useful as Our Analysis
Author: David Ferrick
Product: Maestro Pro, Neural Module, BioCircuit MEA Plate,
preview image
Publication
Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models
Author: Mohajeri K, Yadav R, D'haene E, Boone PM, Erdin S, Gao D, Moyses-Oliveria M, Bhavsar R, Currall BB, O'Keefe K, Burt ND, Lowther C, Lucente D, Salani M, Larson M, Redin C, Dudchenko O, Aiden EL, Menten B, Tai DJC, Gusella JF, Vergult S, Talkowski ME
Product: Maestro Pro,