Assessment of Pro-arrhythmic Effects Using Pluricyte Cardiomyocytes on the Axion Maestro System

Pluricyte® Cardiomyocytes are highly suitable for Axion Maestro MEA assays Pluricyte® Cardiomyocytes are fully functional human induced pluripotent stem cell (hiPSC) derived ventricular cardiomyocytes that are particularly suitable for electrophysiology-based multi-electrode array (MEA) assays for predictive safety pharmacology, toxicity testing and efficacy screening in early drug discovery. The combination of Pluricyte® Cardiomyocytes and the Axion Maestro MEA system enables detailed electrophysiological detection of potential cardiotoxic/proarrhythmic effects of test compounds at 48- and 96-well plate formats. Pluricyte® Cardiomyocytes’ well-pronounced depolarization and repolarization peaks permits easy detection of electrophysiological parameters (e.g. depolarization/repolarization peak amplitudes, beat rate, field potential duration) and facilitate efficient data analysis and interpretation of studies performed with the Axion Maestro MEA system.