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Nature Communications, 10 January 2026
Publication
Functional implications of polygenic risk for schizophrenia in human neurons
Author: PJ M. Deans, K. G. Retallick-Townsley, A. Li, C. Seah, J. Johnson, J. G. Gonzalez, E. Cao, N. Schrode, A. Yu, S. Cartwright, G. Voloudakis, W. Zhang, M. Wang, J. F. Fullard, K. Girdhar, E. Stahl, S. Akbarian, B. Zhang, P. Roussos, P. O’Reilly, L. M. Huckins, and K. J. Brennand
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Nature Communications, 20 December 2025
Publication
SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia
Author: T. Sawada, A. S. Feltrin, Y. Wang, B. Araujo, A. E. McCord, H. H. Giles, S. Han, E. Radulescu, Q. Chen, B. Qamar, A. R. Barbosa, R. S. Jacomini, A.P. R. Lorenzetti, V. Dimitrova, R. Kaneva, V. Vladimirov, J. E. Kleinman, T. M. Hyde, D. R. Weinberger, A. C. M. Paquola, and J. A. Erwin
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Molecular Psychiatry, 28 November 2025
Publication
3D genetic architecture of schizophrenia risk across three neuronal subtypes
Author: S. K. Powell, W. Liao, S. Ghorbani, R. Rigat, C. O’Shea, S. Kammourh, R. Elahi, D. Infante, P. M. Deans, D. J. Le, P. Agarwal, W. Q. Seow, N. Balafkan, K. C. Wang, S. Akbarian, and K. J. Brennand
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Translational Psychiatry, 29 August 2025
Publication
Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders
Author: C. W. Habela, S. Liu, A. Taga, S. Oddoye, R. Dastgheyb, N. Haughey, D. E. Bergles, H. Song, G. Ming, and N. J. Maragakis
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Neuron, 21 July 2025
Publication
Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects
Author: R. M. Walsh, G. W. Crabtree, K. Kalpana, L. Jubierre, S. Y. Koo, G. Ciceri, J. A. Gogos, I. Kruglikov, and L. Studer
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Schizophrenia, 18 February 2025
Publication
miRNA profiling of hiPSC-derived neurons from monozygotic twins discordant for schizophrenia
Author: N. Räsänen, J. Tiihonen, M. Koskuvi, K. Trontti, L. Cheng, A. F. Hill, Š. Lehtonen, O. Vaurio, I. Ojansuu, M. Lähteenvuo, O. Pietiläinen and J. Koistinaho
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Redox Biology, 13 February 2025
Publication
Selenium deficiency impedes maturation of parvalbumin interneurons, perineuronal nets, and neural network activity
Author: A. R. Sasuclark, M. Watanabe, K. Roshto, V. W. Kilonzo, Y. Zhang, and M. W. Pitts
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Molecular Psychiatry Publication, May 2024
Publication
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Author: S. Stern, L. Zhang, M. Wang, R. Wright, I. Rosh, Y. Hussein, T. Stern, A. Choudhary, U. Tripathi, P. Reed, H. Sadis, R. Nayak, A. Shemen, K. Agarwal, D. Cordeiro, D. Peles, Y. Hang, A. P. D. Mendes, T. D. Baul, J. G. Roth, S. Coorapati, M. P. Boks, W. R. McCombie, H. H. Pol, K. J. Brennand, J. M. Réthelyi, R. S. Kahn, M. C. Marchetto and F. H. Gage
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Autism Spectrum Disorder Publication Highlight Cover
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Autism Spectrum Disorder
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Molecular Psychiatry Publication, Dec 2023
Publication
Interplay between hippocampal TACR3 and systemic testosterone in regulating anxiety-associated synaptic plasticity
Author: M. N. Wojtas, M. Diaz-González, N. Stavtseva, Y. Shoam, P. Verma, A. Buberman, I. Izhak, A. Geva, R. Basch, A. Ouro, L. Perez-Benitez, U. Levy, E. Borcel, Á. Nuñez, C. Venero, N. Rotem-Dai, I. Veksler-Lublinsky and S. Knafo
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Quantitative and Qualitative Analysis of Neurotransmitter and Neurosteroid Production in Cerebral Organoids during Differentiation
Publication
Quantitative and Qualitative Analysis of Neurotransmitter and Neurosteroid Production in Cerebral Organoids during Differentiation
Author: S. B. Park, B. Koh, H. S. Kwon, Y. E. Kim, S. S. Kim, S. Cho, T. Kim, M. A. Bae, D. Kang, C. H. Kim and K. Y. Kim
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BJP Publication September 2023
Publication
Pharmacological characterization of SAGE-718, a novel NMDA receptor positive allosteric modulator
Author: J. T. Beckley, T. K. Aman, M. A. Ackley, T. M. Kazdoba, M. C. Lewis, A. C. Smith, B. J. Farley, J. Dai, W. Deats, E. Hoffmann, A. J. Robichaud, J. J. Doherty, and M. C. Quirk
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Cell Genomics Publication - Aug 2023
Publication
Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons
Author: S. Zhang, H. Zhang, M. P. Forrest, Y. Zhou, X. Sun, V. A. Bagchi, A. Kozlova, M. Dos Santos, N. H. Piguel, L. E. Dionisio, A. R. Sanders, Z. P. Pang, X. He, P. Penzes, and J. Duan
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Nature Communications Publication, 24 August 2023
Publication
Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways
Author: W. Zhang, M. Zhang, Z. Xu, H. Yan, H. Wang, J. Jiang, J. Wan, B. Tang, C. Liu, C. Chen and Q. Meng
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Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Author: BK Unda, L Chalil, S Yoon, S Kilpatrick, C Irwin, S Xing, N Murtaza, A Cheng, C Brown, A Afonso, E McCready, GM Ronen, J Howe, A Caye-Eude, A Verloes, BW Doble, L Faivre, A Vitobello, SW Scherer, Y Lu, P Penzes, KK Singh
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Publication
Excitatory dysfunction drives network and calcium handling deficits in 16p11.2 duplication schizophrenia iPSC-derived neurons
Author: Parnell E, Culotta L, Forrest MP, Jalloul HA, Eckman BL, Loizzo DD, Horan KKE, Dos Santos M, Piguel NH, Tai DJC, Zhang H, Gertler TS, Simkin D, Sanders AR, Talkowski ME, Gejman PV, Kiskinis E, Duan J, Penzes P
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Publication
Microglial WNT5A supports dendritic spines maturation and neuronal firing
Author: Yeh H, Woodbury ME, Ingraham Dixie KL, Ikezu T, Ikezu S
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2022 Cell: Tissue- and cell-type-specific meolecular and functional sigantures
Publication
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models
Author: Tai D, Razaz P, Erdin S, Gao D, Wang J, Nuttle X, de Esch CE, Collins RL, Currall BB, O’Keefe K, Burt ND, Yadav R, Wang L, Mohajeri K, Aneichyk T, Ragavendran A, Stortchevoi A, Morini E, Ma W, Lucente D, Hastie A, Kelleher RJ, Perlis RH, Talkowski ME, Gusella JF

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Publication
Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks
Author: Pré D, Wooten AT, Biesmans S, Hinckley S, Zhou H, Sherman SP, Kakad P, Gearhart J, Bang AG.
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Publication
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
Author: Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A, Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ, Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M, Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, Perlis R, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M, Eggan K.
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