Authors: Michael G. McCoy, Anurag Jamaiyar, Grasiele Sausen, Henry S. Cheng, Daniel Pérez-Cremades, Rulin Zhuang, Jingshu Chen, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca and Mark W. Feinberg
Angiogenesis, 08 September 2022
The authors of this study investigated the intramuscular delivery of miR-375 to improve angiogenesis in a diabetic mouse limb ischemia model. The Axion BioSystems Omni was used in the quantification of endothelial wound closure, spheroid sprouting and network formation in HUVECs. The results indicate that miR-375 overexpression leads to an augmentation of these processes, supporting that miR-375 facilitates vessel growth and angiogenesis. All in all, delivery of miR-375 may be a potential therapeutic target for treating human diabetic patients at risk of critical limb ischemia.
