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Publication
Modeling Sporadic Alzheimer’s Disease in Human Brain Organoids under Serum Exposure
Author: Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y.
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
2021 publication altered neuronal support with bipolar disorder
Publication
Altered neuronal support and inflammatory response in bipolar disorder patient-derived astrocytes
Author: Vadodaria KC, Mendes APD, Mei A, Racha V, Erikson G, Shokhirev MN, Oefner R, Heard KJ, McCarthy MJ, Eyler L, Kelsoe JR, Santos R, Marchetto MC, and Gage FH.
Product: Maestro Pro, Neural Module, CytoView MEA Plate,

Neural Co-culture and Glial Interaction

A wide variety of neurons and other cells exist and interact together and the composition of a neural culture can alter development and disease progression
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2020 publication on reduced gaba on neuronal excitability
Publication
Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy
Author: Shore AN, Colombo S, Tobin WF, Petri S, Cullen ER, Dominguez S, Bostick CD, Beaumont MA, Williams D, Khodagholy D, Yang M, Lutz CM, Peng Y, Gelinas JN, Goldstein DB, Boland MJ, Frankel WN, Weston MC.
Product: Maestro Pro, Neural Module, CytoView MEA Plate,
2020 Antiviral paper on COVID-19 and MEA system to assess cardiotoxicity
Publication
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes
Author: Choi SW, Shin JS, Park S-J, Jung E, Park Y-G, Lee J, Kim SJ, Park S-M, Lee J-H, Park S-M, Moon S-H, Ban K, Go YY
Product: Maestro Pro, Cardiac Module, CytoView MEA Plate,

Antiviral Drug Studies

Evaluate the antiviral effects of test compounds by tracking real-time changes in cytopathic effects
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Barrier Function

Monitor cell barrier integrity using a TEER (transepithelial or transendothelial resistance) assay
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Immuno-oncology Assays

Evaluate killing kinetics of immune cells (e.g. CAR T or NK) at physiologically relevant effector cell to target cell ratios
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