Tetramethylenedisulfotetramine alters Ca dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation

Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN.

Toxicology Science, 2012

Summary:

TETS is characterized by spontaneous Ca2+ oscillations and electrical burst discharges from neurons in vitro as recorded by FLIPR and MEA recordings.  Pre-treatment by GABA receptor-postive modulators mitigated the TETS-induced changes.  

Keywords: convulsant, mouse hippocampal neurons

Tetramethylenedisulfotetramine alters Ca dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation