Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK

Shiers S, Mwirigi J, Pradhan G, Kume M, Black B, Barragan-Iglesias P, Moy JK, Dussor G, Pancrazio JJ, Kroener S, Price TJ.

Neuropsychopharmocology, 2019

Summary:

Investigation of mitogen-activated protein kinase-interacting kinase (MNK1/2) targeting for the treatment of peripheral nerve injury-induced neuropathic pain. 

Keywords: neuropathic pain, peripheral nerve, chemotherapy, MNK1/2, nociceptor, inflammation, tomivosertib