Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

Download

Authors: Chad O. Brown, Jarryll A. Uy, Nadeem Murtaza, Elyse Rosa, Alexandria Alfonso, Biren M. Dave, Savannah Kilpatrick, Annie A. Cheng, Sean H. White, Stephen W. Scherer, Karun K. Singh, and Karun K. Singh

Frontiers in Cellular Neuroscience, 15 January 2024

Related Resources
Modeling epilepsy-related SCN2A mutation L1342P with CRISPR/Cas9-edited human-induced pluripotent stem cell-derived cortical spheroids
A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

Related Products

Maestro Edge multiwell MEA system

Maestro Edge

Neural Software Module

Neural Module

Cytoview MEA bottom of the well with electrode placement

CytoView MEA Plate

Envelope
Stay Up to Date With Our Newsletter: