Developmental neurotoxicants disrupt activity in cortical networks on microelectrode arrays: Results of screening 86 compounds during neural network formation

Frank CL, Brown JP, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci, 2017

Summary:

86 compounds were screened for their effect on cortical network function and development. Machine learning algorhythms were used to identify network-disruption. The Maestro MEA assay was shown to be suitable to identify developmental neurotoxicants.

Keywords: developmental, neurotoxicity, neurotoxicology, EPA, screening, network function