Neurons

Toxicology and Applied Pharmacology Publication Sept 2023
Publication
Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration
Author: Y. Ishibashi, N. Nagafuku, K. Kinoshita, A. Okamura, T. Shirakawa, I. Suzuki
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Human and Ecological Risk Assessment Publication, Sept 2023
Publication
New approach methodologies (NAM) to characterize neurotoxic chemicals for use in risk assessment: case study of four neurotoxic pesticides
Author: M. Silva
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Nature Communications Publication, 22 September 2023
Publication
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Author: B. F. Vahsen, S. Nalluru, G. R. Morgan, L. Farrimond, E. Carroll, Y. Xu, K. M. L. Cramb, B. Amein, J. Scaber, A. Katsikoudi, A. Candalija, M. Carcolé, R. Dafinca, A. M. Isaacs, R. Wade-Martins, E. Gray, M. R. Turner, S. A. Cowley and K. Talbot
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Redox Biology Publication, November 2023
Publication
Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability
Author: A. Sri Hari, R. Banerji, L. P. Liang, R. E. Fulton, C. Q. Huynh, T. Fabisiak, P. B. McElroy, J. R. Roede, and M. Patel
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Modulation of GABAA activity: Investigations in hiPSC-derived neural co-cultures and human ion channel assays
Poster
Modulation of GABAA activity: Investigations in hiPSC-derived neural co-cultures and human ion channel assays
Author: K. Rockley, B. Kelly, K. Jones, R. Roberts, M. Morton
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
An integrated in vitro approach for early seizure prediction utilising human derived induced pluripotent stem cells and human ion channel assays
Poster
An integrated in vitro approach for early seizure prediction utilising human derived induced pluripotent stem cells and human ion channel assays
Author: K. L. Rockley, M. Davis, H. Jennings, K. Jones, P. Levesque, R. A. Roberts, M. J. Morton
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
BJP Publication September 2023
Publication
Pharmacological characterization of SAGE-718, a novel NMDA receptor positive allosteric modulator
Author: J. T. Beckley, T. K. Aman, M. A. Ackley, T. M. Kazdoba, M. C. Lewis, A. C. Smith, B. J. Farley, J. Dai, W. Deats, E. Hoffmann, A. J. Robichaud, J. J. Doherty, and M. C. Quirk
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Cell Reports, 29 August 2023
Publication
Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
Author: K. D. Winden, T. T. Pham, N. A. Teaney, J. Ruiz, R. Chen, C. Chen, and M. Sahin
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
Cell Genomics Publication - Aug 2023
Publication
Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons
Author: S. Zhang, H. Zhang, M. P. Forrest, Y. Zhou, X. Sun, V. A. Bagchi, A. Kozlova, M. Dos Santos, N. H. Piguel, L. E. Dionisio, A. R. Sanders, Z. P. Pang, X. He, P. Penzes, and J. Duan
Product: Maestro Edge, Neural Module, CytoView MEA Plate,
SOT Publication Aug 2023
Publication
An integrated approach for early in vitro seizure prediction utilizing hiPSC neurons and human ion channel assays
Author: K. Rockley, R. Roberts, H. Jennings, K. Jones, M. Davis, P. Levesque, M. Morton
Product: Maestro Edge, Neural Module, CytoView MEA Plate,