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2022 Biology Multielectrode array review paper
Publication
Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders
Author: McCready FP, Gordillo-Sampedro S, Pradeepan K, Martinez-Trujillo J and Ellis J.
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Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes
Author: Xian HQ, Blanco C, Bonham K, and Snodgrass HR.
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Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration
Author: Li W, Luo X, Poetsch MS, Oertel R, Nichani K, Schneider M, Strano A, Hasse M, Steiner RP, Cyganek L, Hettwer K, Uhlig S, Simon K, Guan K, and Schubert M.
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Genome Sequencing in a Genetically Elusive Multi-Generational Long QT Syndrome Pedigree Identifies a Novel LQT2-Causative Deeply Intronic KCNH2 Variant
Author: Tobert KE, Tester DJ, Zhou W, Haglund-Turnquist CM, Giudicessi JR, and Ackerman MJ.
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The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
Author: Mishra S, Knupp A, Szabo MP, Williams CA, Kinoshita C, Hailey DW, Wang Y, Andersen OM, and Young JE.
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[PRE-PRINT] SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level
Author: Liu J, Zhang Y, Wu S, Han L, Wang C, Liu S, Simpson E, Liu Y, Wang Y, Shou W, Liu Y, Rubart-von der Lohe M, Wan J, and Yang L.
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[PRE-PRINT] Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.
Author: Sabate-Soler S, Nickels SL, Saraiva C, Berger E, Dubonyte U, Barmpa K, Lan YJ, Kouno T, Jarazo J, Robertson G, Sharif J, Koseki H, Thome C, Shin JW, Cowley SA, and Schwamborn JC.
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In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
Author: Ottavi S, Scarry SM, Mosior J, Ling Y, Roberts J, Singh A, Zhang D, Goullieux L, Roubert C, Bacqué E, Lagiakos HR, Vendome J, Moraca F, Li K, Perkowski AJ, Ramesh R, Bowler MM, Tracy W, Feher VA, Sacchettini JC, Gold BS, Nathan CF, and Aubé J.
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Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate
Author: Thiry L, Clément JP, Haag R, Kennedy TE, and Stifani S.
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[PREPRINT] Efficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues
Author: Limone F, Mitchell JM, San Juan IG, Smith JLM, Raghunathan K, Couto A, Ghosh SD, Meyer D, Mello CJ, Nemesh J, Smith BM, McCarroll S, Pietiläinen O, Nehme R, and Eggan K.
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[PREPRINT] Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Author: Unda BK, Chalil L, Yoon S, Kilpatrick S, Xing S, Murtaza N, Cheng A, Afonso A, McCready E, Ronen G, Howe J, Caye-Eude A, Verloes A, Doble BW, Faivre L, Vitobello A, Scherer SW, Lu Y, Penzes P, and Singh KK.
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Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes
Author: Ulivieri A, Lavra L, Magi F, Morgante A, Calò L, Polisca P, Salehi LB, and Sciacchitano S.
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Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction
Author: Ezerskiy LA, Schoch KM, Sato C, Beltcheva M, Horie K, Rigo F, Martynowicz R, Karch CM, Bateman RJ, and Miller TM.
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Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells
Author: Li Q, Feng Y, Xue Y, Zhan X, Fu Y, Gui G, Zhou W, Richard JP, Taga A, Li P, Mao X, Maragakis NJ, Ying M.
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Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury
Author: Chen X, Zhang J, and Wang K.
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SLC13A5/NaCT overexpression causes disrupted white matter integrity and an autistic-like phenotype
Author: Rigby MJ, Orefice NS, Lawton AJ, Shapiro SL, Yi SY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Li L, Denu JM, and Pugielli L.
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IDH Mutated Gliomas Promote Epileptogenesis through D-2-Hydroxyglutarate Dependent mTOR Hyperactivation
Author: Mortazavi A, Fayed I, Bachani M, Dowdy T, Jahanipour J, Khan A, Owotade J, Walbridge S, Inati SK, Steiner J, Wu J, Gilbert M, Yang CZ, Larion M, Maric D, Ksendzovsky A, and Zaghloul KA.
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Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer’s disease
Author: Lee S, Kim TK, Choi JE, Choi Y, You M, Ryu J, Chun YL, Ham S, Hyeon SJ, Ryu H, Kim H-S, and Im H-I.
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2022 Journal of Medical Chemistry
Publication
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis
Author: Park SJ, Yeon SK, Kim Y, Kim HJ, Kim S, Kim J, Choi JW, Kim B, Lee EH, Kim R, Seo SH, Lee J, Kim JW, Lee H-Y, Hwang H, Bahn Y-S, Cheong E, Park J-H, and Park KD.
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Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays
Author: Pelkonen A, Pistono C, Klecki P, Gómez-Budia M, Dougalis A, Kontinnen H, Stanová I, Fagerlund I, Leinonen V, Korhonen P, and Malm T.
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