Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling

Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG.

JAMA Neurol, 2016

Summary:

Validation of genomic analysis, molecular modeling, and functional profiling (on MEA) to guide pharmacotherapy of neuropathic pain

Keywords: pain, nociceptor, peripheral nerve, dorsal root ganglion, drg, carbamazepine, Nav1.7, man on fire syndrome, burning man, inherited erythromelalgia

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling